This solution brief outlines the combined power of Palo Alto Networks Cortex XDR and Unit 42 Managed Detection and Response (MDR). The package addresses modern cybersecurity complexities where 70% of attacks span multiple surfaces. By unifying AI-driven endpoint security with 24/7 expert monitoring, the solution provides a prevention-first foundation that reduces the mean time to identify and contain threats by up to 90%. The approach is built on four pillars—Prevent, Detect, Investigate, and Respond—integrating unified telemetry across endpoint, cloud, network, identity, and email into a single incident story.